منابع مشابه
Clinical feasibility of molecular imaging of plaque inflammation in atherosclerosis.
Despite substantial advances in the diagnosis and management of coronary artery disease, acute coronary events continue to occur in many patients. It has been increasingly realized that the lesions responsible for acute events may not necessarily be critically obstructive and hence not be associated with inducible ischemia. Various morphologic features of plaque vulnerability have been describe...
متن کاملClinical Feasibility of Molecular Imaging of Plaque Inflammation in Atherosclerosis
Clinical Feasibility of Molecular Imaging of Plaque Inflammation in Atherosclerosis Molecular imaging of various components of atherosclerotic plaques has been proposed, and proof of principle has been demonstrated in experimental models of disease (1). These preclinical studies have predominantly targeted plaque inflammation with the premise that the extent of inflammation would determine the ...
متن کاملClinical Feasibility of Molecular Imaging of Plaque Inflammation in Atherosclerosis
Clinical Feasibility of Molecular Imaging of Plaque Inflammation in Atherosclerosis Molecular imaging of various components of atherosclerotic plaques has been proposed, and proof of principle has been demonstrated in experimental models of disease (1). These preclinical studies have predominantly targeted plaque inflammation with the premise that the extent of inflammation would determine the ...
متن کاملIn vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients.
OBJECTIVES Given the importance of inflammation in atherosclerosis, we sought to determine if atherosclerotic plaque inflammation could be measured noninvasively in humans using positron emission tomography (PET). BACKGROUND Earlier PET studies using fluorodeoxyglucose (FDG) demonstrated increased FDG uptake in atherosclerotic plaques. Here we tested the ability of FDG-PET to measure carotid ...
متن کاملNoninvasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles.
BACKGROUND We have previously shown that microbubbles adhere to leukocytes in regions of inflammation. We hypothesized that these microbubbles are phagocytosed by neutrophils and monocytes and remain acoustically active, permitting their detection in inflamed tissue. METHODS AND RESULTS In vitro studies were performed in which activated leukocytes were incubated with albumin or lipid microbub...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Imaging
سال: 2010
ISSN: 1936-878X
DOI: 10.1016/j.jcmg.2010.09.004